| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Melatonin | 📋 | ✍ | ⛔ | | 38538260 | Melatonin Alleviates BPA-Induced Testicular Apoptosis and Endoplasmic Reticulum Stress |
| Curcumin | 📋 | ✍ | ⛔ | | 38374014 | Curcumin Enhances the Anti-Cancer Efficacy of CDK4/6 Inhibitors in Prostate Cancer |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 36498751 | The Role of Combination Therapy with α-Blockers and Hexanic Extract of Serenoa repens in the Treatment of LUTS/BPH |
| Lycopene | 📋 | ✍ | ⛔ | | 38301353 | Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2 |
| Resveratrol | 📋 | ✍ | ⛔ | | 38262097 | Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention |
| Quercetin | 📋 | ✍ | ⛔ | | 38629094 | Preventive effects of quercetin against inflammation and apoptosis in cyclophosphamide-induced testicular damage |
| Selenium | 📋 | ✍ | ⛔ | | 38608596 | Effects of natural extract interventions in prostate cancer: A systematic review and network meta-analysis |
| Vitamin E | 📋 | ✍ | ⛔ | | 38440903 | Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats |
| Vitamin C | 📋 | ✍ | ⛔ | | 38597120 | Ascorbic acid attenuates gasoline-induced testicular toxicity, sperm quality deterioration, and testosterone imbalance in rats |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38455136 | Unlocking the potential-vitamin D in prostate cancer prevention |
| Zinc | 📋 | ✍ | ⛔ | | 38629506 | Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 38566865 | Unveiling the Anticancer Potential of Pasak Bumi (Eurycoma Longifolia Jack) Root Extract in Prostate Cancer Treatment |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 38226379 | Histological Study of Alteration in Testes and Epididymis of Domestic Rabbits Caused by Tribulus Terrestris and Vitamin E |
| Metformin | 📋 | ✍ | ⛔ | | 38367685 | Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38515566 | Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis |
| CoQ10 | 📋 | ✍ | ⛔ | | 38105612 | Effects of L-Carnitine and Coenzyme Q10 Supplementation on Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia: A Randomized, Controlled, Clinical Trial |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38497852 | Ameliorative effects of L-carnitine as an antioxidant against testicular toxicity induced by AlCl3 in male albino rats |
| EGCG | 📋 | ✍ | ⛔ | | 38392216 | Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis |
| Goji Berry | 📋 | ✍ | ⛔ | | 38543108 | Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 36650745 | Ameliorative effect of ellagic acid and Vitamin C against malathion-induced toxicity in testis of adult Wistar rats |
| Medicinal Plants | 📋 | | | | 36902686 | Role of Phytotherapy in the Management of BPH: A Summary of the Literature |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37536455 | The potential protective effect of melatonin and N-acetylcysteine alone and in combination on opioid-induced testicular dysfunction and degeneration in rat |
| Pomegranate | 📋 | | ⛔ | | 37445909 | Evaluation of the Antioxidant and Antiangiogenic Activity of a Pomegranate Extract in BPH-1 Prostate Epithelial Cells |
| Genistein | 📋 | ✍ | ⛔ | | 37959856 | The Role of Genistein in Mammalian Reproduction |
| Ginseng | 📋 | ✍ | ⛔ | | 38333335 | Effect of Carob and Ginseng Supplements on Semen Analysis Parameters, Sexual Function, and Sex Hormones in Infertile Men: Double-Blind, Randomized Controlled Trial Study |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38391402 | Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents |
| Micronutrients | 📋 | | ⛔ | | 38001791 | Effect of Micronutrients and L-Carnitine as Antioxidant on Sperm Parameters, Genome Integrity, and ICSI Outcomes: Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| Apigenin | 📋 | ✍ | ⛔ | | 38314599 | Radiation-induced Testicular Damage in Mice: Protective Effects of Apigenin Revealed by Histopathological Evaluation |
| Hesperidin | 📋 | ✍ | ⛔ | | 38216069 | Protective Role of Hesperidin in Finasteride-Induced Testicular Toxicity in Adult Male Wistar Rats: Insights into Oxidative Stress, Apoptosis, and ultrastructure of seminiferous tubules |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38388663 | α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38268782 | Alleviation of carbendazim toxicity effect by Moringa oleifera oil and Linum usitatissimum L . oil on testes of male rats: Physiological, histological and in silico study |
| Pine Bark | 📋 | ✍ | ⛔ | | 38391402 | Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38056144 | Astaxanthin alleviates chronic prostatitis/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38595651 | Ameliorative impacts of propolis against testicular toxicity promoted by doxorubicin |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37779581 | Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats |
| Silymarin | 📋 | ✍ | ⛔ | | 38500117 | Camel milk or silymarin could improve the negative effects that experimentally produced by aflatoxin B1 on rat's male reproductive system |
| Antioxidants | 📋 | | ⛔ | | 38700012 | The influence of oral antioxidants on men with infertility: a systemic review |
| Ashwagandha | 📋 | ✍ | ⛔ | | 37532077 | Withania somnifera ameliorates sexual arousal and impotence in stressed sexually sluggish male rats by modulating neurotransmitters and NO/cGMP/PDE5α pathway |
| L-Arginine | 📋 | ✍ | ⛔ | | 37908749 | Efficacy of L-arginine and Pycnogenol ® in the treatment of male erectile dysfunction: a systematic review and meta-analysis |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 37872365 | Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities |
| Tomato | 📋 | | ⛔ | | 37726932 | Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH |
| Berberine | 📋 | ✍ | ⛔ | | 35949309 | Berberine protects against diclofenac sodium-induced testicular impairment in mice by its anti-oxidant and anti-apoptotic activities |
| Icariin | 📋 | ✍ | | | 37716031 | Icariin inhibits prostate cancer bone metastasis and destruction via suppressing TAM/CCL5-mediated osteoclastogenesis |
| Ginsenosides | 📋 | ✍ | ⛔ | | 37102430 | Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt |
| Fisetin | 📋 | ✍ | ⛔ | | 36813806 | Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 37919464 | The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study |
| Pterostilbene | 📋 | ✍ | ⛔ | | 37064475 | Inhibition of miR-20a by pterostilbene facilitates prostate cancer cells killed by NK cells via up-regulation of NKG2D ligands and TGF-β1down-regulation |
| Saffron | 📋 | ✍ | ⛔ | | 38694315 | Saffron extract as an emerging novel therapeutic option in reproduction and sexual health: recent advances and future prospectives |
| Chrysin | 📋 | ✍ | ⛔ | | 37592178 | Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation |
| Crocin | 📋 | ✍ | ⛔ | | 38458495 | Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 35420721 | Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38449457 | Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization |
| Date | 📋 | | ⛔ | | 38483941 | Date (Phoenix dactylifera L. Mill) fruit enhances sexual performance via modulation of oxido-inflammatory mediators and purinergic signaling in hypertensive male rats |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38286926 | Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38254705 | Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice |
| Phytochemicals | 📋 | | | | 38067423 | Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 38370896 | The antioxidant role of pumpkin ( Cucurbita pepo) seed extract against acute reproductive toxicity by uranyl acetate in male rats |
| Food | 📋 | | | | 38715795 | Mendelian randomization reveals the impact of diet on infertility in men and women |
| Naringin | 📋 | ✍ | ⛔ | | 38419883 | Protective effects of naringin against oxaliplatin-induced testicular damage in rats: Involvement of oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histopathology |
| Thymoquinone | 📋 | | ⛔ | | 38658488 | The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-Ä°nduced Testicular Tissue Damage |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 37409447 | Toxicity of methomyl insecticides to testicular cells and protective effect of folic acid |
| Kaempferol | 📋 | ✍ | ⛔ | | 38387328 | Kaempferol alleviates bisphenol A reproductive toxicity in rats in a dose-dependent manner |
| Licorice Root | 📋 | ✍ | ⛔ | | 36532850 | Effects of Glycyrrhiza Glabra (Licorice) Root Extract on the Hormones, Serum Biochemicals, and Hematological Parameters in Dogs with Benign Prostatic Hyperplasia |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 37938242 | Antioxidant activity of Flemingia praecox and Mucuna pruriens and their implications for male fertility improvement |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 38670510 | Mitigating effect of pomegranate peel extract against the furan induced testicular injury by apoptosis, steroidogenic enzymes and oxidative stress |
| Silibinin | 📋 | ✍ | | | 38608596 | Effects of natural extract interventions in prostate cancer: A systematic review and network meta-analysis |
| CAPE | 📋 | | | | 38480977 | Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT |
| Carvacrol | 📋 | ✍ | ⛔ | | 38133725 | Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes |
| Green Tea | 📋 | ✍ | ⛔ | | 38561489 | Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 37630724 | Modified Citrus Pectin Treatment in Non-Metastatic Biochemically Relapsed Prostate Cancer: Long-Term Results of a Prospective Phase II Study |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 37273043 | Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses |
| Rutin | 📋 | ✍ | ⛔ | | 38535787 | Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic-Pituitary-Gonadal Axis |
| Cinnamon | 📋 | ✍ | ⛔ | | 38669415 | Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study |
| Gallic Acid | 📋 | | ⛔ | | 35196152 | Gallic acid ameliorates di-(2-ethylhexyl) phthalate-induced testicular injury in adult mice |
| Ginger | 📋 | ✍ | ⛔ | | 36809190 | Effects of Ginger on Disgust, Sexual Arousal, and Sexual Engagement: A Placebo-Controlled Experiment |
| Pygeum Africanum | 📋 | ✍ | ⛔ | | 35435166 | [Effectiveness of treatment with Pygeum africanum in patients with lower urinary tract symptoms and benign prostatic hyperplasia: a cross-sectional study in the real-world clinical practice in Spain (The PROFIT Study)] |
| Turmeric | 📋 | ✍ | ⛔ | | 38391402 | Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents |
| Arctigenin | 📋 | | | | 38254705 | Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice |
| Baicalein | 📋 | ✍ | ⛔ | | 36388170 | Baicalein Alleviates Testicular Ischemia-Reperfusion Injury in a Rat Model of Testicular Torsion-Detorsion |
| Bromelain | 📋 | ✍ | ⛔ | | 36544851 | Extracorporeal shock wave therapy in association with bromelain and escin for the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome |
| Cordycepin | 📋 | | | | 37846111 | [Effect of cordycepin on CX43 expression in the corpus cavernosum of type II diabetes induced erectile dysfunction in rats] |
| Dihydroartemisinin | 📋 | | | | 38014931 | Dihydroartemisinin ameliorated the inflammatory response and regulated miRNA-mRNA expression profile of chronic nonbacterial prostatitis |
| Eugenol | 📋 | | | | 38253778 | Eugenol alleviates acrylamide-induced rat testicular toxicity by modulating AMPK/p-AKT/mTOR signaling pathway and blood-testis barrier remodeling |
| Frankincense | 📋 | ✍ | ⛔ | | 38391402 | Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents |
| Galangal | 📋 | ✍ | ⛔ | | 37143784 | Assessing the effect of Alpinia galanga extract on the treatment of SSRI-induced erectile dysfunction: A randomized triple-blind clinical trial |
| Graviola | 📋 | ✍ | ⛔ | | 32878595 | Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 35058429 | Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16 |
| Maca Root | 📋 | ✍ | ⛔ | | 38518815 | A novel approach of using Maca root as a radioprotector in a rat testicular damage model focusing on GRP78/CHOP/Caspase-3 pathway |
| Naringenin | 📋 | ✍ | ⛔ | | 37204407 | Naringenin ameliorates aluminum toxicity-induced testicular dysfunctions in mice by suppressing oxidative stress and histopathological alterations |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 35570547 | Nigella sativa oil alleviates mouse testis and sperm abnormalities induced by BPA: potentially through redox homeostasis? |
| Procyanidins | 📋 | | ⛔ | | 35489465 | Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 38068715 | The Use of Soy Isoflavones in the Treatment of Prostate Cancer: A Focus on the Cellular Effects |
| Spirulina | 📋 | ✍ | ⛔ | | 37910183 | Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride-induced testicular challenge in adult rats: role of CYP11A1, StAR, and HSD-3B expressions |
| Withaferin A | 📋 | | | | 37848702 | Withaferin-A attenuates diabetes mellitus induced male reproductive dysfunction mediated by ERα in brain and testes of Swiss albino mice |
| Acacetin | 📋 | | | | 37298192 | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| Amygdalin | 📋 | ✍ | ⛔ | | 37910183 | Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride-induced testicular challenge in adult rats: role of CYP11A1, StAR, and HSD-3B expressions |
| Catechins | 📋 | | | | 37154035 | Effect of dietary antioxidants on the risk of prostate cancer. Systematic review and network meta-analysis |
| Dandelion | 📋 | ✍ | ⛔ | | 38674879 | Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats |
| Fig | 📋 | | ⛔ | | 36317103 | The Effects of Ficus carica on Male and Female Reproductive Capabilities in Rats |
| Fluted Gourd | 📋 | | | | 36056790 | Fluted pumpkin seeds protect the spermatogenesis score index and testicular histology of caffeine treated rats |
| Gingerol | 📋 | ✍ | | | 38166796 | Structure based docking and biological evaluation towards exploring potential anti-cancerous and apoptotic activity of 6-Gingerol against human prostate carcinoma cells |
| Indian Gooseberry | 📋 | | ⛔ | | 33845263 | Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements |
| Luteolin | 📋 | ✍ | ⛔ | | 37904332 | Luteolin induces ferroptosis in prostate cancer cells by promoting TFEB nuclear translocation and increasing ferritinophagy |
| Mulberry | 📋 | | ⛔ | | 35398183 | Protective role of the dried white mulberry extract on the reproductive damage and fertility in rats treated with carmustine |
| Nobiletin | 📋 | ✍ | | | 34709572 | Nobiletin protects against diabetes-induced testicular injury via hypophysis-gonadal axis upregulation and amelioration of oxidative stress |
| Salidroside | 📋 | | | | 37943949 | Salidroside Ameliorates Furan-Induced Testicular Inflammation in Relation to the Gut-Testis Axis and Intestinal Apoptosis |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 37807970 | Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome-mediated Caspase-1/GSDMD pyroptosis pathway |
| Walnut | 📋 | | ⛔ | | 28945497 | Antiproliferative Activity of Walnut (Juglans regia L.) Proteins and Walnut Protein Hydrolysates |
| Aloe Vera | 📋 | ✍ | ⛔ | | 34155868 | Protective Effect of Aloe vera Gel against Cisplatin-Induced Testicular Damage, Sperm Alteration and Oxidative stress in Rats |
| Andrographolide | 📋 | | | | 30800220 | Andrographolide induces DNA damage in prostate cancer cells |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38474045 | Astragalus membranaceus Extract Induces Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Heat Shock Protein 27 and Androgen Receptor in Prostate Cancers |
| Bee Pollen | 📋 | ✍ | ⛔ | | 37486857 | Rapeseed Bee Pollen Alleviates Chronic Non-bacterial Prostatitis via Regulating Gut Microbiota |
| Bee Venom | 📋 | ✍ | ⛔ | | 37517867 | Melittin inhibits tumor cell migration and enhances cisplatin sensitivity by suppressing IL-17 signaling pathway gene LCN2 in castration-resistant prostate cancer |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36612074 | Plasma Micronutrient Profile of Prostate Cancer Cases Is Altered Relative to Healthy Controls-Results of a Pilot Study in South Australia |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38148931 | The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 35871254 | Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression |
| Butyrate | 📋 | | ⛔ | | 38577936 | Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration‑resistant prostate cancer cells |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37201366 | Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells |
| Caffeine | 📋 | ✍ | ⛔ | | 38433013 | Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia |
| Carotenoids | 📋 | ✍ | ⛔ | | 36183866 | Carotenoids in female and male reproduction |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 36877529 | Chlorogenic acid alleviated testicular inflammation and apoptosis in tunicamycin induced endoplasmic reticulum stress |
| Cocoa | 📋 | ✍ | ⛔ | | 37697053 | Do "testosterone boosters" really increase serum total testosterone? A systematic review |
| Cordyceps | 📋 | ✍ | ⛔ | | 33776321 | A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats |
| Cornus | 📋 | | | | 38606866 | Ethanol Extracts of Cornus alba Improve Benign Prostatic Hyperplasia by Inhibiting Prostate Cell Proliferation through Modulating 5 Alpha-Reductase/Androgen Receptor Axis-Mediated Signaling |
| Cranberry | 📋 | ✍ | ⛔ | | 33136465 | Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats |
| Diosmin | 📋 | ✍ | ⛔ | | 36327569 | Novel protective effect of diosmin against cisplatin-induced prostate and seminal vesicle damage: Role of oxidative stress and apoptosis |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 36384263 | Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance by Impairing the PI3K/AKT/ Nrf2/GPX4 Signalling Pathway in Docetaxel-Resistant PC3 Prostate Cancer Cells |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38430206 | Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA |
| Fucoidan | 📋 | ✍ | ⛔ | | 36135731 | Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer |
| Garlic | 📋 | ✍ | ⛔ | | 38581015 | Effects of garlic (Allium sativum L) and Citrullus colocynthis (L.) Schrad individually and in combination on male reproductive damage due to diabetes: suppression of the AGEs/RAGE/Nox-4 signaling pathway |
| Gotu Kola | 📋 | ✍ | ⛔ | | 36124918 | Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways |
| Hesperetin | 📋 | | | | 30179627 | Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 33930204 | Hyaluronic acid injection in the glans penis for the treatment of refractory premature ejaculation: A prospective, controlled study |
| Morin | 📋 | | | | 38219219 | Morin hydrate ameliorates heat-induced testicular impairment in a mouse model |
| Myricetin | 📋 | | ⛔ | | 36169847 | Dietary myricetin assuages atrazine-mediated hypothalamic-pituitary-testicular axis dysfunction in rats |
| Neferine | 📋 | | | | 37762540 | Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species |
| Oleuropein | 📋 | | | | 35914339 | Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 34984064 | Phytosterols in hull-less pumpkin seed oil, rich in ∆ 7-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats |
| Tangeretin | 📋 | | | | 37298192 | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| Taurine | 📋 | ✍ | ⛔ | | 38008966 | The protective effect of taurine on cyclophosphamide-induced testicular toxicity in rats |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38462874 | Effect of Serum Vitamin B12 Levels on Premature Ejaculation |
| Astragalin | 📋 | | | | 35384303 | An emerging strategy for tracing the anti-erectile dysfunction components of raw and salt-processed semens of Astragali Complanati by combinatory liquid chromatography-mass spectrometry-based quantitative analysis, efficacy assessment on impotent rats and partial least squares regression |
| Astragalosides | 📋 | ✍ | ⛔ | | 38622523 | Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway |
| Baicalin | 📋 | ✍ | ⛔ | | 37357241 | Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway |
| Beets | 📋 | ✍ | ⛔ | | 37483802 | Beet leaf (beta vulgaris L.) extract attenuates iron-induced testicular toxicity: Experimental and computational approach |
| Betaine | 📋 | ✍ | ⛔ | | 38488483 | Betaine postpones hyperglycemia-related senescence in ovarian and testicular cells: Involvement of RAGE and β-galactosidase |
| Capsaicin | 📋 | ✍ | ⛔ | | 38700794 | Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice |
| Chlorella | 📋 | ✍ | ⛔ | | 38114777 | The Role of Chlorella vulgaris in Attenuating Infertility Induced by Cadmium Chloride via Suppressing Oxidative Stress and Modulating Spermatogenesis and Steroidogenesis in Male Rats |
| Cinnamaldehyde | 📋 | | | | 32960365 | Cinnamaldehyde induces endogenous apoptosis of the prostate cancer-associated fibroblasts via interfering the Glutathione-associated mitochondria function |
| Coconut Oil | 📋 | | ⛔ | | 38629097 | Therapeutic potential of virgin coconut oil in mitigating sodium benzoate- model of male infertility: Role of Nrf2/Hmox-1/NF-kB signaling pathway |
| Daidzein | 📋 | ✍ | ⛔ | | 35584629 | Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment |
| Dihydroquercetin | 📋 | | | | 36198370 | In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress |
| Escin | 📋 | ✍ | ⛔ | | 36544851 | Extracorporeal shock wave therapy in association with bromelain and escin for the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 35996879 | Effect of ferulic acid on testicular damage caused by torsion-detorsion in rats |
| Fish Oil | 📋 | ✍ | ⛔ | | 37684043 | Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 34238751 | [Fucoxanthin induces prostate cancer PC-3 cell apoptosis by causing mitochondria dysfunction and oxidative stress] |
| Ginger extract | 📋 | ✍ | ⛔ | | 33405108 | Zingiber officinale ethanolic extract attenuates oxidative stress, steroidogenic gene expression alterations, and testicular histopathology induced by sodium arsenite in male rats |
| Holy Basil | 📋 | ✍ | ⛔ | | 35355764 | Effects of Ocimum tenuiflorum on Induced Testicular Degeneration by Filgrastim in Wistar Rats |
| Isoliquiritigenin | 📋 | | | | 38493580 | Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33151048 | Oral Testofen, L-Citrulline, Resveratrol, and Caffeine Supplement Drink Improves Sexual Function in Men with Phosphodiesterase 5 Inhibitors: Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study |
| Olive Oil | 📋 | ✍ | ⛔ | | 36695747 | Extra virgin olive oil ameliorates high-fat diet-induced seminal and testicular disorders by modulating the cholesterol pathway |
| Onion | 📋 | ✍ | ⛔ | | 34400937 | Onion ( Allium cepa) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: A Comprehensive Review |
| Papaya | 📋 | ✍ | ⛔ | | 33433362 | Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia via the TRAF6/TAK1/MEK/NF-κB pathway |
| Polyphenols | 📋 | | | | 35319120 | Diet, herbs and erectile function: A good friendship! |
| Punicalagin | 📋 | ✍ | ⛔ | | 28709945 | Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells |
| Raspberry | 📋 | ✍ | ⛔ | | 35629073 | Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway |
| Royal Jelly | 📋 | ✍ | ⛔ | | 37171774 | Activation of Nrf-2 Transcription Factor and Caspase Pathway with Royal Jelly Reduces Fluoride Induced Testicular Damage and Infertility in Rats |
| Trans-Resveratrol | 📋 | | | | 36674697 | Inhibition of ANO1 by Cis- and Trans-Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells |
| Wormwood | 📋 | ✍ | ⛔ | | 38392223 | Anticancer Effect by Combined Treatment of Artemisia annua L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells |
| Yohimbine | 📋 | ✍ | | | 35118966 | Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis |
| Acai Berry | 📋 | ✍ | ⛔ | | 38370884 | Comparing the effects of Cyperus esculentus hydroethanolic extract and Euterpe oleracea on reproductive efficacy against cadmium-induced testicular toxicity in male rats |
| Allicin | 📋 | ✍ | ⛔ | | 38639521 | Protective effect of allicin on ischemia-reperfusion injury caused by testicular torsion-detorsion in rats |
| Almond | 📋 | | ⛔ | | 36349403 | Nutraceutical potential of almond fruits in managing diabetes-related erectile dysfunction: Effect on Nrf-2 level and smooth muscle/collagen ratio |
| Aloe-Emodin | 📋 | | | | 38348349 | Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study |
| Anethole | 📋 | | | | 28745237 | Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis |
| Avocado | 📋 | ✍ | ⛔ | | 37871299 | Avocado Oil ( Persea americana) Reduces Epithelial Proliferation on Benign Prostatic Hyperplasia |
| Broccoli | 📋 | | ⛔ | | 37821783 | The Effectiveness of Time in Treatment with Vitamin C and Broccoli Extract on Cadmium Poisoning in Mice: Histological Changes of Testicular Tissue and Cell Apoptotic Index |
| Carnosic Acid | 📋 | | | | 34679726 | Curcumin and Carnosic Acid Cooperate to Inhibit Proliferation and Alter Mitochondrial Function of Metastatic Prostate Cancer Cells |
| Chamomile | 📋 | ✍ | ⛔ | | 36860921 | Drug Standardization through Pharmacognostic Approaches and Estimation of Anticancer Potential of Chamomile ( Matricaria chamomilla L.) using Prostate-Cancer cell lines: An In-vitro Study |
| Citral | 📋 | | | | 36163582 | The evaluation of citral effects on experimental unilateral testicular ischemia/reperfusion injury |
| Coffee | 📋 | ✍ | ⛔ | | 35995710 | Coffee Intake, Caffeine Metabolism Genotype, and Survival Among Men with Prostate Cancer |
| Costus | 📋 | ✍ | ⛔ | | 37375368 | HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells |
| DHEA | 📋 | ✍ | ⛔ | | 34273785 | The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health |
| Diosgenin | 📋 | | | | 36681316 | Diosgenin inhibits prostate cancer progression by inducing UHRF1 protein degradation |
| Emodin | 📋 | | ⛔ | | 37062702 | Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway |
| Eurycomanone | 📋 | | | | 33793798 | Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats |
| Formononetin | 📋 | | | | 25301361 | Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells |
| Grape | 📋 | | ⛔ | | 35464055 | Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid, Vitis vinifera L. and Ginkgo biloba, Compared to Placebo, Avanafil or a Combination of Nutraceutical Plus Avanafil in Males With Type 2 Diabetes Mellitus With Erectile Dysfunction |
| Hyperoside | 📋 | | | | 38305391 | Hyperoside Inhibits RNF8-mediated Nuclear Translocation of β-catenin to Repress PD-L1 Expression and Prostate Cancer |
| Isoflavones | 📋 | ✍ | ⛔ | | 36829927 | The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer |
| Kudzu Root | 📋 | ✍ | ⛔ | | 36771648 | Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats |
| L-Glutamine | 📋 | ✍ | ⛔ | | 37033138 | Glutamine Supplementation Attenuates Bisphenol A-Induced Testicular Toxicity in Rats |
| L-Proline | 📋 | ✍ | ⛔ | | 35716071 | Beneficial effect of L-Proline supplementation on the quality of human spermatozoa |
| Lotus | 📋 | | ⛔ | | 33964997 | The antiandrogenic effect of neferine, liensinine, and isoliensinine by inhibiting 5-α-reductase and androgen receptor expression via PI3K/AKT signaling pathway in prostate cancer |
| Lychee | 📋 | | ⛔ | | 37871755 | Total flavonoids of Litchi chinensis Sonn. seed inhibit prostate cancer growth in bone by regulating the bone microenvironment via inactivation of the HGFR/NF-κB signaling pathway |
| Mangiferin | 📋 | | ⛔ | | 34400143 | Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis |
| Mangosteen | 📋 | ✍ | ⛔ | | 37046780 | α-Mangostin Promotes In Vitro and In Vivo Degradation of Androgen Receptor and AR-V7 Splice Variant in Prostate Cancer Cells |
| Marigold | 📋 | ✍ | ⛔ | | 35691152 | α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression |
| Morusin | 📋 | | | | 37120705 | Anticancer Effects of Morusin in Prostate Cancer via Inhibition of Akt/mTOR Signaling Pathway |
| NAD | 📋 | | | | 38646657 | NAD+ precursors promote the restoration of spermatogenesis in busulfan-treated mice through inhibiting Sirt2-regulated ferroptosis |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 37440992 | The Impact of Origanum vulgare Supplementation on Human Asthenozoospermic Sperm Parameter Quality |
| Peanut | 📋 | | ⛔ | | 32202087 | Peanut Sprout Extracts Cultivated with Fermented Sawdust Medium Inhibits Benign Prostatic Hyperplasia In Vitro and In Vivo |
| Perilla | 📋 | ✍ | | | 38449453 | Effects of Perilla frutescens Var. Acuta in Busulfan-Induced Spermatogenesis Dysfunction Mouse Model |
| Phloretin | 📋 | | | | 35888117 | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
| Phytoestrogens | 📋 | | ⛔ | | 36441471 | Effects of phytoestrogens on reproductive organ health |
| Piperine | 📋 | ✍ | ⛔ | | 38528700 | Piperine mitigates oxidative stress, inflammation, and apoptosis in the testicular damage induced by cyclophosphamide in mice |
| Probiotics | 📋 | ✍ | ⛔ | | 38171106 | Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice |
| Puerarin | 📋 | ✍ | ⛔ | | 37516022 | Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 37354258 | Polysaccharides from Lentinus edodes prevent acquired drug resistance to docetaxel in prostate cancer cells by decreasing the TGF-β1 secretion of cancer-associated fibroblasts |
| Sirtuin Activators | 📋 | | | | 35847357 | Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation |
| Soy | 📋 | ✍ | ⛔ | | 37314422 | Variation of inflammatory indexes in patients with chronic abacterial prostatitis treated with an herbal compound/extract |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 34849072 | Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS |
| Stevia | 📋 | ✍ | ⛔ | | 37415512 | Ameliorative effect of Stevia rebaudiana Bertoni on sperm parameters, in vitro fertilization, and early embryo development in a streptozotocin-induced mouse model of diabetes |
| Syringic Acid | 📋 | | | | 37801787 | Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate |
| Tanshinone | 📋 | | | | 37932808 | PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics |
| Thymol | 📋 | ✍ | ⛔ | | 37403475 | Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats |
| Urolithins | 📋 | | | | 25962506 | Urolithin A causes p21 up-regulation in prostate cancer cells |
| Vitamin A | 📋 | ✍ | ⛔ | | 35215508 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 38475697 | Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 29432837 | Vitamin K2, a Menaquinone Present in Dairy Products Targets Castration-Resistant Prostate Cancer Cell-Line by Activating Apoptosis Signaling |
| White Mushrooms | 📋 | | ⛔ | | 33388344 | White button mushroom (Agaricus bisporus) disrupts androgen receptor signaling in human prostate cancer cells and patient-derived xenograft |
| White Tea | 📋 | | ⛔ | | 27637002 | White tea intake prevents prediabetes-induced metabolic dysfunctions in testis and epididymis preserving sperm quality |
| Aged Garlic | 📋 | ✍ | ⛔ | | 33803601 | S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells |
| Angelica | 📋 | ✍ | ⛔ | | 35634973 | Antitumor mechanism of combination of Angelica gigas and Torilis japonica in LNCaP prostate cancer cells via G1 arrest and inhibition of Wnt/β-catenin and androgen receptor signaling |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 37880723 | Association between polyunsaturated fatty acid intake and the prevalence of erectile dysfunction: A cross-sectional analysis of the NHANES 2001-2004 |
| Argan Oil | 📋 | ✍ | ⛔ | | 17174037 | Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines |
| Asiatic Acid | 📋 | | | | 37209940 | Asiatic acid exhibits antimetastatic activity in human prostate cancer cells by modulating the MZF-1/Elk-1/Snail signaling axis |
| Aspirin | 📋 | | ⛔ | | 37648741 | Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies |
| Beta-Lapachone | 📋 | | | | 15829436 | Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells |
| Biochanin A | 📋 | | | | 35584629 | Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36167706 | Momordica charantia fruit extract with antioxidant capacity improves the expression of tyrosine-phosphorylated proteins in epididymal fluid of chronic stress rats |
| Black Ginger | 📋 | ✍ | ⛔ | | 38194854 | A systematic review and meta-analysis of animal and human studies demonstrates the beneficial effects of Kaempferia parviflora on metabolic syndrome and erectile dysfunction |
| Burdock | 📋 | | ⛔ | | 30003584 | The protective effects of Arctium lappa L. Extract on testicular injuries induced by ethanol in rats |
| Carrot | 📋 | | ⛔ | | 34829524 | Physiological Roles of Red Carrot Methanolic Extract and Vitamin E to Abrogate Cadmium-Induced Oxidative Challenge and Apoptosis in Rat Testes: Involvement of the Bax/Bcl-2 Ratio |
| Celery | 📋 | | ⛔ | | 34062080 | The effect of Apium graveolens L., Levisticum officinale and Calendula officinalis L. on cell viability, membrane integrity, steroidogenesis, and intercellular communication in mice Leydig cells in vitro |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 28638867 | ANTITUMOR EFFECTS OF CHRYSANTHEMIN IN PC-3 HUMAN PROSTATE CANCER CELLS ARE MEDIATED VIA APOPTOSIS INDUCTION, CASPASE SIGNALLING PATHWAY AND LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL |
| Coptis Chinensis | 📋 | | ⛔ | | 34457027 | Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Coptis chinensis Franchin Polycystic Ovary Syndrome |
| Corn | 📋 | | ⛔ | | 35466676 | Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis |
| D-Limonene | 📋 | ✍ | ⛔ | | 37773484 | D-Limonene Alleviates Oxidative Stress Injury of the Testis Induced by Arsenic in Rat |
| Diallyl Sulfide | 📋 | | | | 32785828 | Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways |
| DIM | 📋 | ✍ | ⛔ | | 36835033 | The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models |
| Diosmetin | 📋 | | | | 37413905 | Fenofibrate and Diosmetin in a rat model of testicular toxicity: New insight on their protective mechanism through PPAR-α/NRF-2/HO-1 signaling pathway |
| Echinacea | 📋 | ✍ | ⛔ | | 33996978 | Echinacea purpurea Ethanol Extract Improves Male Reproductive Dysfunction With Streptozotocin-Nicotinamide-Induced Diabetic Rats |
| Echinacoside | 📋 | | | | 34424528 | Echinacoside Protects Against Dysfunction of Spermatogenesis Through the MAPK Signaling Pathway |
| Elderberry | 📋 | ✍ | ⛔ | | 36127818 | An elderberry-supplemented diet improves spermatogenesis in mice with busulfan-induced azoospermia |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 32455127 | Effect of Origanum vulgare Essential Oil Supplementation on the Advanced Parameters of Mobility and on the Integrity of Human Sperm DNA |
| Fenugreek | 📋 | ✍ | ⛔ | | 35707467 | Trigonella foenum-graecum L. and Psoralea corylifolia L. Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats through Suppression of Oxidative Stress |
| Fish | 📋 | | ⛔ | | 20844069 | Fish consumption and prostate cancer risk: a review and meta-analysis |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 38268782 | Alleviation of carbendazim toxicity effect by Moringa oleifera oil and Linum usitatissimum L . oil on testes of male rats: Physiological, histological and in silico study |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 23199523 | Effects of EPA, γ-Linolenic Acid or Coenzyme Q10 on Serum Prostate-Specific Antigen Levels: A Randomised, Double-Blind Trial |
| Ginkgetin | 📋 | | | | 25611086 | Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity |
| Hazelnut | 📋 | | ⛔ | | 34664725 | Effects of hazelnut supplemented diet on doxorubicin-induced damage of reproductive system in male rats |
| Hydroxytyrosol | 📋 | | | | 34572980 | Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells |
| Icaritin | 📋 | | | | 37992492 | The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 34914300 | [Morinda officinalis how extract up-regulates the expression of SPAG11T and inhibits that of miR-210 in the testis tissue of varicocele rats] |
| Iodine | 📋 | ✍ | ⛔ | | 37192707 | Protective effects of iodine on rat prostate inflammation induced by sex hormones and on the DU145 prostate cancer cell line treated with TNF |
| Irisin | 📋 | | | | 38643847 | Irisin as an emerging target in the regulation of reproductive functions in health and disease |
| L-Carnosine | 📋 | ✍ | ⛔ | | 38018900 | Anticancer actions of carnosine in cellular models of prostate cancer |
| L-Theanine | 📋 | ✍ | ⛔ | | 37198140 | Protective Effect of l-Theanine on Cyclophosphamide-Induced Testicular Toxicity in Mice |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 33752438 | [L-tryptophan as dietetic supplement and treatment for hot flashes, astenia, and insomnia in cancer patients] |
| Lemongrass | 📋 | ✍ | ⛔ | | 33438563 | Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improve Chemotherapy Activity in Prostate Cancer Cells |
| Linalool | 📋 | | ⛔ | | 38657337 | Therapeutic potential of the linalool against cadmium-induced testicular tissue damage |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 37077161 | Dietary intake and biomarkers of linoleic acid and risk of prostate cancer in men: A systematic review and dose-response meta-analysis of prospective cohort studies |
| Lutein | 📋 | ✍ | ⛔ | | 38314281 | Possible mechanisms involved in the protective effect of lutein against cyclosporine-induced testicular damage in rats |
| Magnesium | 📋 | ✍ | ⛔ | | 36407550 | Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001-2004 |
| Maitake Mushrooms | 📋 | | ⛔ | | 19055833 | Possible immunotherapeutic potentiation with D-fraction in prostate cancer cells |
| MSM | 📋 | ✍ | ⛔ | | 30339981 | Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells |
| Myrrh | 📋 | ✍ | ⛔ | | 25591732 | Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells |
| Neem | 📋 | ✍ | | | 35957716 | Exploring the therapeutic potential of Neem ( Azadirachta Indica) for the treatment of prostate cancer: a literature review |
| Nimbolide | 📋 | | | | 36007677 | Nimbolide enhances the antitumor effect of docetaxel via abrogation of the NF-κB signaling pathway in prostate cancer preclinical models |
| NMN | 📋 | ✍ | ⛔ | | 37851298 | Nicotinamide Mononucleotide Improves Spermatogenic Disorders in Aluminum-Exposed Rats by Modulating the Glycolytic Pathway |
| Orange | 📋 | | ⛔ | | 31347717 | Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats |
| Paeonol | 📋 | | | | 35678254 | Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway |
| Parsley | 📋 | | ⛔ | | 38614435 | Protective Effect of Petroselinum Crispum Methanolic Extract against Acrylamide-induced Reproductive Toxicity in Male Rats through NF-ĸB, Kinesin, steroidogenesis Pathways |
| Parthenolide | 📋 | | | | 37949423 | Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue |
| Patchouli | 📋 | ✍ | ⛔ | | 36507482 | Patchouli alcohol inhibits GPBAR1-mediated cell proliferation, apoptosis, migration, and invasion in prostate cancer |
| PEA | 📋 | ✍ | ⛔ | | 34202665 | Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 19308266 | Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells |
| Pomegranate Seed extract | 📋 | | ⛔ | | 32219129 | Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats |
| Poria Mushrooms | 📋 | ✍ | | | 35398386 | Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats |
| Progesterone | 📋 | ✍ | ⛔ | | 36303641 | Varicocele: An Endocrinological Perspective |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 37960775 | Network pharmacology to explore the molecular mechanisms of Prunella vulgaris for treating thyroid cancer |
| Pueraria Mirifica | 📋 | ✍ | ⛔ | | 30710233 | The effects of Pueraria mirifica extract, diadzein and genistein in testosterone-induced prostate hyperplasia in male Sprague Dawley rats |
| PUFA | 📋 | | | | 33737530 | Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats |
| Rapamycin | 📋 | ✍ | | | 36598515 | Effect of rapamycin treatment in human seminoma TCam-2 cells through inhibition of G1-S transition |
| Red Sage | 📋 | ✍ | ⛔ | | 37994101 | Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/ HO-1 Activation |
| Retinoic Acid | 📋 | | | | 33531604 | Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression |
| Roselle | 📋 | ✍ | ⛔ | | 32888148 | Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa) and their potential effects on monosodium glutamate-induced testicular damage in rat |
| Rosemary | 📋 | ✍ | ⛔ | | 33152908 | Rosemary (Rosmarinus officinalis L.) extract inhibits prostate cancer cell proliferation and survival by targeting Akt and mTOR |
| Sage | 📋 | ✍ | ⛔ | | 38012170 | Salvia officinalis restores semen quality and testicular functionality in cadmium-intoxicated male rats |
| Schisandra | 📋 | ✍ | ⛔ | | 31744253 | The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat |
| Shilajit | 📋 | ✍ | ⛔ | | 29947420 | Profertility effects of Shilajit on cadmium-induced infertility in male mice |
| Spermidine | 📋 | | | | 37453063 | Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer |
| Strawberry | 📋 | ✍ | ⛔ | | 34255375 | Strawberry fruit (Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury |
| Sweet Potato | 📋 | | ⛔ | | 35458672 | An Extensive Pharmacological Evaluation of New Anti-Cancer Triterpenoid (Nummularic Acid) from Ipomoea batatas through In Vitro, In Silico, and In Vivo Studies |
| Tannic Acid | 📋 | ✍ | ⛔ | | 35317115 | Sperm and testicular dysfunction during cecal ligation and puncture-induced sepsis in male rats and effects of tannic acid through reducing testicular oxidative stress and inflammation |
| Taro Root | 📋 | | ⛔ | | 36873908 | In-vivo and in-silico studies revealed the molecular mechanisms of Colocasia esculenta phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α-reductase and α1-adrenoceptor |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 31266276 | Could pollen extract in association with vitamins be favorable in the reduction of chronic prostatic inflammation? A case-series analysis |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37589322 | Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 32418772 | Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART) |
| Vitamins | 📋 | | | | 38178948 | Vitamin D supplementation for improving sperm parameters in infertile men: A systematic review and meta-analysis of randomized clinical trials |
| Watermelon | 📋 | | ⛔ | | 37417854 | Impact of Watermelon (Citrallus lanatus) on Male Fertility |
| Wine | 📋 | | ⛔ | | 37373577 | Red Wine and Sexual Function in Men: An Original Point of View |
| Wogonin | 📋 | ✍ | ⛔ | | 32781062 | Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways |
| Zingerone | 📋 | | | | 38629098 | Effects of zingerone on rat induced testicular toxicity by sodium arsenite via oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and autophagy pathways |
| Alfalfa | 📋 | | ⛔ | | 38103848 | Effect of Medicago sativa seed powder (Plus vitamin E vs. vitamin E alone) on semen analysis in men with idiopathic infertility: A double blind randomized clinical trial |
| Almond Oil | 📋 | | ⛔ | | 25992248 | The histological and histometrical effects of Urtica dioica extract on rat's prostate hyperplasia |
| Andrographis | 📋 | ✍ | ⛔ | | 35922691 | Bioassay-Guided extraction of andrographis paniculata for intervention of in-vitro prostate cancer progression in metabolic syndrome environment |
| Anise | 📋 | ✍ | ⛔ | | 37389431 | Protective effectiveness of anise against testicular ischemia and reperfusion injury: An experimental study in rats |
| Anthocyanidins | 📋 | | | | 35406634 | The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer |
| Anthocyanins | 📋 | ✍ | ⛔ | | 35406634 | The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer |
| Apple Polyphenols | 📋 | | ⛔ | | 37571225 | Red-Fleshed Apple Flavonoids Extract Alleviates Male Reproductive Injury Caused by Busulfan in Mice |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 29923211 | Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease |
| Asafoetida | 📋 | ✍ | ⛔ | | 31516858 | Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines |
| Ashitaba | 📋 | ✍ | ⛔ | | 30686791 | Angelica keiskei (Ashitaba) powder and its functional compound xanthoangelol prevent heat stress-induced impairment in sperm density and quality in mouse testes |
| Avocado Oil | 📋 | | ⛔ | | 36068645 | Ameliorative effect of avocado oil against lufenuron induced testicular damage and infertility in male rats |
| Basil | 📋 | ✍ | ⛔ | | 31667861 | Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation-induced testicular injury |
| Bay Leaf | 📋 | | ⛔ | | 36590130 | Aqueous extract of bay leaf ( Laurus nobilis) ameliorates testicular toxicity induced by aluminum chloride in rats |
| Bergamot | 📋 | ✍ | ⛔ | | 33919028 | A Flavonoid-Rich Extract from Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, Shows Protective Effects in a Murine Model of Cadmium-Induced Testicular Injury |
| Bergamottin | 📋 | | | | 34570813 | Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis |
| Beta-Cryptoxanthin | 📋 | | | | 27101804 | Preventive effects of β-cryptoxanthin against cadmium-induced oxidative stress in the rat testis |
| Betulinic Acid | 📋 | | | | 35489292 | Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation |
| Bilberry | 📋 | ✍ | ⛔ | | 32929801 | Vaccinium myrtillus L. extract and its native polyphenol-recombined mixture have anti-proliferative and pro-apoptotic effects on human prostate cancer cell lines |
| Black Tea | 📋 | ✍ | ⛔ | | 12566493 | Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice |
| Black Tea Polyphenols | 📋 | | | | 23715786 | Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction |
| Blackberry | 📋 | | ⛔ | | 32670587 | Rubus apetalus (Rosaceae) improves spermatozoa characteristics, antioxidant enzymes and fertility potential in unilateral cryptorchid rats |
| Blueberry | 📋 | ✍ | ⛔ | | 21950543 | Effectiveness of Antioxidants (Propolis, Blueberry, Vitamin E) Associated With Verapamil in the Medical Management of Peyronie's Disease: A Study of 151 Cases |
| Boric Acid | 📋 | ✍ | ⛔ | | 37562273 | Therapeutic role of boron on acrylamide-induced nephrotoxicity, cardiotoxicity, neurotoxicity, and testicular toxicity in rats: Effects on Nrf2/Keap-1 signaling pathway and oxidative stress |
| Brazil Nut | 📋 | | ⛔ | | 32550168 | Benefits of the Consumption of Brazil Nut ( Bertholletia excelsa) Extract in Male Reproductive Parameters of Streptozotocin-Induced Diabetic Rats |
| Cabbage | 📋 | | ⛔ | | 35598098 | Cabbage (Brassica oleracea) mitigates lead (II) acetate-induced testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormonal axis and down-regulation of oxido-inflammatory reactions |
| Calycosin | 📋 | | | | 37663231 | Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway |
| Camellia | 📋 | | ⛔ | | 36466393 | Combining effect of camellia oil and squalene on hyperlipidemia-induced reproductive damage in male rats |
| Cantaloupe | 📋 | | ⛔ | | 35942162 | The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats |
| Caraway | 📋 | | ⛔ | | 28956846 | Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on Prostate Cells |
| Cardamom | 📋 | ✍ | ⛔ | | 37403247 | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil-induced hypothyroidism male BALB/c mice |
| Cardamonin | 📋 | | | | 34187951 | Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation |
| Carnosol | 📋 | | | | 23531917 | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| Casein Protein | 📋 | ✍ | ⛔ | | 37663799 | Casein and pea enriched high-protein diet attenuates arsenic provoked apoptosis in testicles of adult rats |
| Cashew | 📋 | | ⛔ | | 35112369 | Effect of cashew (Anacardium occidentale L.) nut-supplemented diet on steroidogenic enzymes, hormonal and oxidative imbalances, and sperm parameters in cisplatin-induced reproductive toxicity in male rats |
| Catalpol | 📋 | | | | 33310037 | Catalpol ameliorates diabetes-induced testicular injury and modulates gut microbiota |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 17976968 | Inhibitory effect of essential oils against herpes simplex virus type 2 |
| Cherry | 📋 | | ⛔ | | 31507215 | Sweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolism |
| Chia Seeds | 📋 | | ⛔ | | 38255724 | Evaluation of Salvia hispanica as a Therapeutic Agent against Sodium Arsenic-Induced Testicular Toxicity in a Male Rats Model |
| Chickpea | 📋 | | ⛔ | | 38474555 | Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders-A Preliminary In Vitro Study |
| Chokeberry | 📋 | ✍ | ⛔ | | 32481550 | The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 31408283 | Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum |
| Citrus Fruits | 📋 | | ⛔ | | 15514967 | Do Dietary Lycopene and Other Carotenoids Protect Against Prostate Cancer? |
| Clove | 📋 | | ⛔ | | 15530165 | Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats |
| Clove Essential Oil | 📋 | | ⛔ | | 32352181 | The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats |
| Coconut | 📋 | | ⛔ | | 36407391 | Regulation of male sex hormones strongly heightens copulation behavior indices in rat's model administered Cocos nucifera husks extract |
| Colostrum | 📋 | ✍ | ⛔ | | 31805571 | A Prospective, Open-Label Comparison of Tamsulosin plus Serenoa repens and Bovine Colostrum versus Tamsulosin Alone in the Treatment of Benign Prostatic Hyperplasia |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 19005974 | White Button Mushroom (Agaricus Bisporus) Exhibits Antiproliferative and Proapoptotic Properties and Inhibits Prostate Tumor Growth in Athymic Mice |
| Copper | 📋 | ✍ | ⛔ | | 36407550 | Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001-2004 |
| Coriander | 📋 | | ⛔ | | 30417420 | The determination of the potential anticancer effects of Coriandrum sativum in PC-3 and LNCaP prostate cancer cell lines |
| Corn Silk | 📋 | ✍ | ⛔ | | 37579272 | Protective effect of aqueous and methanolic extracts of corn silk on nicotine-induced reproductive system disorders in male mice |
| Coumaric acid | 📋 | | | | 38513920 | Molecular insights into the antioxidative and anti-inflammatory effects of P-coumaric acid against bisphenol A-induced testicular injury: In vivo and in silico studies |
| Crocetin | 📋 | | | | 33802807 | Crocetin Mitigates Irradiation Injury in an In Vitro Model of the Pubertal Testis: Focus on Biological Effects and Molecular Mechanisms |
| Cryptotanshinone | 📋 | | | | 36462735 | Cryptotanshinone modulates proliferation, apoptosis, and fibrosis through inhibiting AR and EGFR/STAT3 axis to ameliorate benign prostatic hyperplasia progression |
| Cucumber | 📋 | | ⛔ | | 37310102 | Cucumis sativus (Cucurbitaceae) seed oil prevents benzo(a)pyrene-induced prostate cancer in vitro and in vivo |
| Cyanidin | 📋 | ✍ | | | 23199305 | Purple Corn Color Inhibition of Prostate Carcinogenesis by Targeting Cell Growth Pathways |
| D-Mannose | 📋 | ✍ | ⛔ | | 35142655 | Mannose inhibits the growth of prostate cancer through a mitochondrial mechanism |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 22693649 | Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice |
| Emu Oil | 📋 | ✍ | ⛔ | | 26700214 | Topical treatment for acute phase Peyronie's disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study |
| Eucalyptus | 📋 | ✍ | ⛔ | | 33134128 | Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats |
| Eucommia | 📋 | ✍ | ⛔ | | 36460131 | Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity |
| Fennel | 📋 | ✍ | ⛔ | | 33867335 | Fennel fortified diet: New perspective with regard to fertility and sex hormones |
| Fiber | 📋 | ✍ | ⛔ | | 38243202 | Higher insoluble fiber intake is associated with a lower risk of prostate cancer: results from the PLCO cohort |
| Flavonoids | 📋 | | ⛔ | | 33069836 | Interplay between male reproductive system dysfunction and the therapeutic effect of flavonoids |
| Folate | 📋 | ✍ | ⛔ | | 17099205 | The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility |
| Geniposide | 📋 | | | | 36063855 | Geniposide attenuates spermatogenic dysfunction via inhibiting endoplasmic reticulum stress in male mice |
| Glabridin | 📋 | | | | 36029289 | The toxicity mechanism of glabridin in prostate cancer cells is involved in reactive oxygen species-dependent PI3K/Akt pathway: Integrated utilization of bioinformatic analysis and in vitro test validation |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 32488776 | Prostatotropic Action of Glycyrrhizic Acid Disodium Salt in Benign Prostatic Hyperplasia Models |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 35460094 | Grapefruit peel extract mitigates paroxetine-induced erectile dysfunction in rats through stimulation of erectile response, antioxidant status, and inhibition of key enzymes related with impaired penile erection |
| Guava | 📋 | | ⛔ | | 33807287 | Pharmacological Effects of Guava ( Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro |
| Haritaki | 📋 | ✍ | ⛔ | | 18047445 | Herbal mixtures containing the mushroom Ganoderma lucidum improve recovery time in patients with herpes genitalis and labialis |
| Helichrysum | 📋 | | ⛔ | | 31558010 | Pumpkin seeds, Centella asiatica, Boswellia, Helichrysum, acetate vitamin E, Melaleuca alternifolia and hyaluronic acid phytocomplex monotherapy effects in patients with chronic pelvic pain syndrome |
| Honey | 📋 | ✍ | ⛔ | | 34198728 | Review on Bee Products as Potential Protective and Therapeutic Agents in Male Reproductive Impairment |
| Honokiol | 📋 | | | | 38364735 | Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 34913451 | Chestnut polysaccharides restore impaired spermatogenesis by adjusting gut microbiota and the intestinal structure |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 35529823 | Protective effects of Equisetum arvense methanolic extract on testicular tissue disorders in streptozotocin-induced diabetic murine model |
| Isorhamnetin | 📋 | | | | 35782651 | Isorhamnetin: a flavonoid, attenuated doxorubicin-induced testicular injury via regulation of steroidogenic enzymes and apoptotic signaling gene expression in male rats |
| Kava Root | 📋 | ✍ | ⛔ | | 34368644 | Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1 |
| L-Lysine | 📋 | ✍ | ⛔ | | 17848742 | Inhibitory Effects of a Nutrient Mixture on Human Testicular Cancer Cell Line NT 2/DT Matrigel Invasion and MMP Activity |
| Lauric Acid | 📋 | ✍ | | | 37211320 | Lauric acid improves hormonal profiles, antioxidant properties, sperm quality and histomorphometric changes in testis and epididymis of streptozotocin-induced diabetic infertility rats |
| Lemon Balm | 📋 | ✍ | ⛔ | | 29876952 | Can Melissa officinalis improve chromatin structure and sperm parameters in a rat model of varicocele? |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 29501481 | Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule |
| Licochalcones | 📋 | | | | 19711916 | Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway |
| Ligustilide | 📋 | | | | 35626012 | Ligustilide Inhibits Tumor Angiogenesis by Downregulating VEGFA Secretion from Cancer-Associated Fibroblasts in Prostate Cancer via TLR4 |
| Lime Essential Oil | 📋 | ✍ | ⛔ | | 31662741 | Histoprotective Effect of Essential Oil from Citrus aurantifolia in Testosterone-Induced Benign Prostatic Hyperplasia Rat |
| Loquat | 📋 | ✍ | ⛔ | | 34740154 | Cell suspension culture extract of Eriobotrya japonica attenuates growth and induces apoptosis in prostate cancer cells via targeting SREBP-1/FASN-driven metabolism and AR |
| Lovage | 📋 | | ⛔ | | 34062080 | The effect of Apium graveolens L., Levisticum officinale and Calendula officinalis L. on cell viability, membrane integrity, steroidogenesis, and intercellular communication in mice Leydig cells in vitro |
| Lupeol | 📋 | | | | 36072559 | Role of lupeol in chemosensitizing therapy-resistant prostate cancer cells by targeting MYC, β-catenin and c-FLIP: in silico and in vitro studies |
| Magnolol | 📋 | | | | 38364735 | Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats |
| Mango Leaf | 📋 | | ⛔ | | 37674830 | Counteractive effects of extracts of Mangifera indica on testes of Wistar Rat exposed to cyclophosphamide |
| Marjoram | 📋 | | ⛔ | | 35740046 | Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation |
| Marjoram Essential Oil | 📋 | | ⛔ | | 36249946 | Origanum majorana essential oil improves the rat's sexual behavior and testicular oxidative damage induced by imidacloprid via modulating the steroidogenesis pathways |
| Mastic | 📋 | ✍ | ⛔ | | 35747351 | The effects of P. atlantica as a libido booster and sexual enhancer on the reproductive system of male rats |
| Motherwort | 📋 | ✍ | ⛔ | | 38669415 | Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study |
| Mustard | 📋 | | ⛔ | | 15139111 | [An Experimental study(II) on the Inhibition of Prostatic Hyperplasia by Extract of Seeds of Brassica Alba] |
| Myrtle | 📋 | ✍ | ⛔ | | 38682543 | Ameliorative effects of Myrtus communis L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 36986980 | The Leaf Essential Oil of Myrtus communis subsp. tarentina (L.) Nyman: From Phytochemical Characterization to Cytotoxic and Antimigratory Activity in Human Prostate Cancer Cells |
| Nicotinamide | 📋 | ✍ | ⛔ | | 34101148 | Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38079523 | BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin |
| Noni | 📋 | | ⛔ | | 34661119 | Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer |
| Nuciferine | 📋 | | | | 29633800 | The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study |
| Nuts | 📋 | | ⛔ | | 37977328 | Nut consumption and fertility: a systematic review and meta-analysis |
| Oleic Acid | 📋 | | ⛔ | | 37738211 | Aging-Related Mitochondrial Dysfunction is Associated with Fibrosis in Benign Prostatic Hyperplasia |
| Olive Polyphenols | 📋 | | | | 31838605 | Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 36131086 | Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 28829378 | Antioxidant and Anticancer Activities of Essential Oil from Gannan Navel Orange Peel |
| Oregano | 📋 | ✍ | ⛔ | | 32966695 | Origanum vulgare L. leaves extract alleviates testis and sperm damages induced by finasteride: Biochemical, Immunohistological and apoptosis genes based evidences |
| Osmanthus | 📋 | ✍ | ⛔ | | 37687413 | Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts |
| Oyster | 📋 | | ⛔ | | 36097247 | Effects of Aerobic Exercise Combined with Oyster Peptide Supplement on the Formation of CTX-induced Late-Onset Hypogonadism in Male Rats |
| Peas | 📋 | | ⛔ | | 37663799 | Casein and pea enriched high-protein diet attenuates arsenic provoked apoptosis in testicles of adult rats |
| Pectin | 📋 | ✍ | ⛔ | | 17513886 | Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure |
| Pelargonidin | 📋 | | | | 23199305 | Purple Corn Color Inhibition of Prostate Carcinogenesis by Targeting Cell Growth Pathways |
| Peony | 📋 | | ⛔ | | 28783760 | Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells |
| Persimmon | 📋 | | ⛔ | | 28811126 | Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis |
| Phellodendron | 📋 | ✍ | ⛔ | | 34735909 | The bioactive alkaloids identified from Cortex Phellodendri ameliorate benign prostatic hyperplasia via LOX-5/COX-2 pathways |
| Phytosterols | 📋 | | | | 34984064 | Phytosterols in hull-less pumpkin seed oil, rich in ∆ 7-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats |
| Pineapple | 📋 | ✍ | ⛔ | | 34842384 | Ameliorating Effect of Pineapple Juice on the Obesity-Induced Testicular Impairment in Male Wistar Rat |
| PQQ | 📋 | ✍ | ⛔ | | 37935689 | Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice |
| Prickly Pear | 📋 | | ⛔ | | 34622044 | Comparative study between in vivo- and in vitro-derived extracts of cactus ( Opuntis ficus-indica L. Mill) against prostate and mammary cancer cell lines |
| Proanthocyanidins | 📋 | | | | 38088309 | The effects of proanthocyanidin on testicular toxicity in rats exposed to a glyphosate-based herbicide |
| Pumpkin | 📋 | | ⛔ | | 15514967 | Do Dietary Lycopene and Other Carotenoids Protect Against Prostate Cancer? |
| Red Clover | 📋 | ✍ | ⛔ | | 35164615 | Trifolium pratense extract increases testosterone and improves sperm characteristics and antioxidant status in diabetic rats |
| Rehmannia | 📋 | ✍ | ⛔ | | 35273587 | The Herb Pair Radix Rehmanniae and Cornus Officinalis Attenuated Testicular Damage in Mice With Diabetes Mellitus Through Butyric Acid/Glucagon-Like Peptide-1/Glucagon-Like Peptide-1 Receptor Pathway Mediated by Gut Microbiota |
| Rosehip | 📋 | ✍ | ⛔ | | 36698735 | Protective effects of hydroalcoholic extract of Rosa canina L. fruit on cyclophosphamide-induced testicular toxicity in mice |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36640564 | Rosemary (Rosmarinus officinalis L.) essential oil alleviates testis failure induced by Etoposide in male rats |
| Rosmarinic Acid | 📋 | ✍ | | | 28586512 | Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats |
| Safflower | 📋 | ✍ | ⛔ | | 33894286 | Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress |
| Safranal | 📋 | | | | 33392189 | Safranal Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2 |
| Sage Essential Oil | 📋 | | ⛔ | | 32455127 | Effect of Origanum vulgare Essential Oil Supplementation on the Advanced Parameters of Mobility and on the Integrity of Human Sperm DNA |
| Salvianolic Acid | 📋 | | | | 35069978 | Attenuation Effect of Salvianolic Acid B on Testicular Ischemia-Reperfusion Injury in Rats |
| SAMe | 📋 | ✍ | ⛔ | | 35303200 | S-Adenosylmethionine affects ERK1/2 and STAT3 pathway in androgen-independent prostate cancer cells |
| Schisandrins | 📋 | | | | 37425035 | Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors |
| Scutellarein | 📋 | | | | 36257765 | Scutellarein stimulates human sperm function by increasing the levels of intracellular calcium and tyrosine phosphorylation |
| Scutellarin | 📋 | | | | 28737827 | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells |
| Seafood | 📋 | | | | 18996866 | A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality |
| Senolytics | 📋 | | | | 36552790 | Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer |
| Sesame Oil | 📋 | | ⛔ | | 33648043 | The effects of sesame oil and different doses of estradiol on testicular structure, sperm parameters, and chromatin integrity in old mice |
| Sesamin | 📋 | ✍ | | | 34588981 | Protective Effects of Sesamin on Cytoxan-Induced Spermatogenesis Dysfunction by Regulating RNF8-ubH2A/ubH2B Pathways in Male Mice |
| Sesamol | 📋 | | | | 34466348 | In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy |
| Shogaol | 📋 | | | | 28872603 | Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell |
| Skullcap | 📋 | ✍ | ⛔ | | 35505400 | Scutellaria barbata D.Don (SBD) extracts suppressed tumor growth, metastasis and angiogenesis in Prostate cancer via PI3K/Akt pathway |
| Soy Protein | 📋 | ✍ | ⛔ | | 33432829 | Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy |
| Spearmint | 📋 | | ⛔ | | 31646410 | Nicotine-induced oxidative stress, testis injury, AChE inhibition and brain damage alleviated by Mentha spicata |
| Spinach | 📋 | | ⛔ | | 15514967 | Do Dietary Lycopene and Other Carotenoids Protect Against Prostate Cancer? |
| Tamarind | 📋 | | ⛔ | | 28830817 | Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp |
| Tea | 📋 | | | | 35636601 | Association between tea consumption and semen quality among 1385 healthy Chinese men |
| Tea Polyphenols | 📋 | | | | 23862225 | [Tea polyphenols inhibits the proliferation of prostate cancer DU145 cells] |
| Telmisartan | 📋 | | ⛔ | | 35463822 | Combinatorial effects of telmisartan and docetaxel on cell viability and metastatic gene expression in human prostate and breast cancer cells |
| UDCA | 📋 | ✍ | ⛔ | | 38454160 | Ursodeoxycholic acid ameliorates erectile dysfunction and corporal fibrosis in diabetic rats by inhibiting the TGF-β1/Smad2 pathway |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 19959891 | Effects of pantothenic acid on testicular function in male rats |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 31266276 | Could pollen extract in association with vitamins be favorable in the reduction of chronic prostatic inflammation? A case-series analysis |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 36432448 | Biotin Enhances Testosterone Production in Mice and Their Testis-Derived Cells |
| Vitexin | 📋 | | | | 35693443 | Chemoprotective effect of vitexin against cisplatin-induced biochemical, spermatological, steroidogenic, hormonal, apoptotic and histopathological damages in the testes of Sprague-Dawley rats |
| Whey Protein | 📋 | ✍ | ⛔ | | 35355865 | Cysteine-Rich Whey Protein Isolate (CR-WPI) Ameliorates Erectile Dysfunction by Diminishing Oxidative Stress via DDAH/ADMA/NOS Pathway |
| Withanolides | 📋 | | | | 30536034 | Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells |
| Wormwood Essential Oil | 📋 | | ⛔ | | 36379416 | Apoptosis induction of essential oils from Artemisia arborescens L. in human prostate cancer cells |
| Yerba Mate | 📋 | ✍ | ⛔ | | 36696705 | Protective effects of Yerba mate (IIex paraguariensis) on prostate cancer development |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 36649922 | Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction |
